研究テーマ

• Structural biology of viral assemblies and host–virus interfaces using cryo-electron microscopy to guide vaccine and antiviral development (Structural Virology)

キーワード

• Virus
• Cryo-electron microscopy
• Structural biology
• Vaccine design
• Host-pathogen interaction
• Macromolecular complexes
• Antiviral strategies

研究概要

• We aim to elucidate the molecular architecture and mechanisms of viral assemblies and their interactions with host cellular components to inform the rational design of vaccines and antiviral therapeutics. Our research is centered on understanding the structural biology of viruses, viral replication complexes, and virus–host interfaces using cutting-edge cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET).
• Focusing on pathogenic RNA viruses such as alphaviruses and coronaviruses, we study their structural organization at multiple levels—from intact virions to subcellular replication compartments. These viruses often evade immune detection and establish persistent infections. By analyzing the 3D structures of viral particles and replication complexes in near-native states, we aim to identify conserved structural elements and dynamic processes that are essential for viral infectivity and immune evasion.
• Our group also investigates how viruses interact with host cell membranes, proteins, and lipids to hijack cellular machinery for replication and assembly. Through high-resolution structural analysis of these host–virus interactions, we uncover potential targets for therapeutic intervention.
• Additionally, we collaborate with immunologists and vaccine developers to structurally characterize virus–antibody complexes. These studies provide insight into neutralizing epitopes and help to guide antigen design for next-generation vaccines, particularly for emerging and re-emerging viral threats.
• Through the integration of structural virology, immunology, and vaccine science, our goal is to contribute to the development of broadly effective and structurally-informed vaccines and antivirals. This research will also support preparedness for future pandemics by building a foundational understanding of virus structure and host interaction principles.