Research Theme

• Molecular and genetic analysis of Host-Virus interactions in viruses causing acute respiratory infections
• Elucidation of the mechanisms of viral strategy in host shutoff
• Functional analysis of host genes using advanced genetic engineering and its application to vaccine production

Keyword

• Influenza virus
• SARS-CoV-2
• Hantaviruses
• Host shutoff

Overview of Research

• Viruses leverage the functions of both host and viral proteins to replicate efficiently. Focusing on both the virus and the host, this research analyzes the molecular and genetic mechanisms by which viruses hijack infected host cell machinery.
• Viruses that cause acute respiratory infections, such as influenza virus, SARS-CoV-2, and hantaviruses, possess a “host shutoff” function that suppresses host gene expression in infected cells. Through this mechanism, viruses inhibit host antiviral responses and promote the expression of viral proteins, thereby modulating an environment advantageous for viral replication and transmission. While the mechanisms and targets of this host shutoff share commonalities among certain viruses, some display distinct, unique strategies. We aim to elucidate the molecular mechanisms of host shutoff induced by these viruses to establish the foundations for novel therapeutic interventions.
• By applying cutting-edge genetic engineering techniques, we perform detailed functional analyses of host genes that have been challenging to analyze using conventional methods. Furthermore, by extending this technology to enhance viral replication efficiency, we aim to improve productivity in next-generation cell-culture vaccine manufacturing.