Research Theme

• Development of genetically engineered mouse models for infectious disease research
• Development of platforms for microbiome-based animal experiments

Keyword

• Genetic engineering
• Humanized mice
• Microbiome manipulation

Overview of Research

• Developing panels of animal models with differential susceptibility to infectious diseases by applying genome editing technologies across diverse mouse strains.
• Generating humanized mouse models through human gene replacement, mouse gene knockout, and human cell engraftment to improve translational relevance for human disease research.
• Establishing microbiome evaluation platforms by controlling microbial communities through germ-free derivation, bacterial inoculation, and fecal microbiota transplantation (FMT) in developed mouse models.